Lifestyle

New breakthrough in breast cancer research

UNIVERSITY of Queensland researchers have discovered a way of predicting cancer-free survival in breast cancer patients and identified a new treatment target.

The researchers, led by Professor George Muscat from UQ's Institute for Molecular Bioscience (IMB), has found that breast cancer patients with a particular genetic 'signature' are more likely to survive without their cancer spreading.

Professor Muscat and his team also identified a protein that could be targeted by cancer drugs.

"We examined tissue samples from over 100 breast cancer patients and discovered that those with low levels of the enzyme PRMT2 had a better chance of surviving without their cancer metastasising," Professor Muscat said.

"This enzyme has the ability to affect hundreds of genes so we also examined these genes and the proteins they produce.

"We identified one of these proteins, RORγ, as a druggable protein, meaning it appears to be a good target for treatment."

Professor Muscat said this discovery suggests in future doctors will be able to more confidently predict outcomes in some breast cancer patients, and subsequently improve treatment regimes.

"It also opens the way to develop a new and novel drug for the treatment of breast cancer."

Professor Muscat and his team are now beginning to examine experimental drugs that target RORγ   to evaluate if any are suitable to decrease the growth of tumours and control metastasis.

Cancer Council Queensland spokesperson Katie Clift said the organisation was proud to fund Professor Muscat's research with a grant of $100,000 for 2014.

"Professor Muscat's research is very promising and we look forward to his findings assisting future treatment of breast cancer, improving survival rates in Queensland.

"Around 2900 Queenslanders are diagnosed with breast cancer every year, and about 500 people die from the disease.

"Funding local studies is imperative, and we are proud to see such world-class research being undertaken at the University of Queensland."

The discovery, published in scientific journal Molecular Endocrinology, was supported by The University of Queensland and Cancer Council Queensland and used samples and data provided by a National Breast Cancer Foundation Collaborative Research Program.

IMB  acknowledges the contributions of co-authors PhD student Tae Gyu Oh, Dr Peter Bailey, Dr Eloise Dray, Dr Aaron Smith and Dr Dennis Dowhan, and members of the NBCF Collaborative Research Program.

The Institute for Molecular Bioscience, a research institute of The University of Queensland, aims to improve quality of life by advancing medical genomics, drug discovery and biotechnology.

More information about Cancer Council Queensland is available at www.cancerqld.org.au or 13 11 20.
 

Topics:  breast cancer cancer council



How to survive a bushfire in your car

IT SOUNDS like a nightmare, but it can happen.

Eight reasons to join the RFS

SPREAD across 93% of Queensland, the Rural Fire Service has about 36,000 volunteers. And you could be one of them.

What if my insurer gives me grief?

CLAIMING your insurance cover after a natural disaster can go one of two ways. It can be a breeze, or like pulling teeth.

New funding improves North Burnett disaster radio

FILE PHOTO: The council has received funding for a new digital radio system.

The council has received about $200,000 for the system.

Council signals more land rights agreements on the way

Bundaberg Regional Council mayor Jack Dempsey, Gladstone Regional Council mayor Matt Burnett and North Burnett mayor Rachel Chambers sign a land use agreement with the Port Curtis Coral Coast People.

This follows a historic signing last week.

Security guard punched outside the Club Hotel

OPERATION JABBAH: Police restrain a man outside the Club Hotel in May during a police operation.

Police call on revellers to drink responsibly

Local Partners

Rob's off to start a fresh new chapter

AFTER more than three decades delivering fruit and vegies to loyal customers across Bundaberg, Robert Ward is packing up his ute and retiring.


Kernaghan's a 'boy from the bush' with a timeless quality

Country music singer Lee Kernaghan.

Lee Kernaghan is celebrating the 25th year of his breakthrough song.

What's on: Saturday, December 3

Not sure what to do today? We've got you covered

Head to the sugar museum for a sweet taste of history

Cutting the ribbon to officially open the revamped Sugar Museum at Fairymead House is Mayor Jack Dempsey and Fairymead House Team Leader Hayley Vale.

Learn about the industry that made Bundy what it is

EXCLUSIVE: Meet Robert Irwin, wildlife photographer

SNAPPER: Apart from wildlife, photography is Robert Irwin's great passion.

Steve's boy has a passion for photography

Louis Tomlinson's tribute to late mother

Louis Tomlinson's new single is a tribute to his late mother.

Justin Timberlake stuns students with secret class

Justin Timberlake stunned high school students in Sydney

Carrie Fisher says Ford will be bugged by affair confession

Carrie Fisher is sure Harrison Ford is annoyed at her

Dakota Fanning rekindles romance with childhood sweetheart

Dakota Fanning rekindles romance with ex

Jennifer Lawrence apologises to the people of Hawaii

Jennifer Lawrence sorry for 'offensive' story

Essential to get new Maroochydore CBD fundamentals right

LOOKING AHEAD: The central business district at Maroochydore is planned to be the heart of the Sunshine Coast.

SunCentral reports good progress on 53ha Sunshine Coast city heart

'Crucial' farm land eyed by defence department

Lawson Geddes moving the Brangus cattle to higher ground - which is the land the Defence Department is interested taking for the Shoalwater Bay expansion.

"You can't have one without the other.”

Former Shark Show for sale for $1.3 million

Vic Hislop at the old Shark Show.

TALK about a jaws-dropping real estate opportunity.

There's a whole lot of luxury in this home

The Endeavour Foundation's latest prize home in Mountain Creek.

WHEN it comes to desirable homes, it's hard to go past a prize home.

Ipswich City Properties asset portfolio retains its value

Ipswich City Council Administration Building, South Street, Ipswich. Photo: Claudia Baxter / The Queensland Times

New website launched by Ipswich City Council

Ready to SELL your property?

Post Your Ad Here!