Lifestyle

New breakthrough in breast cancer research

UNIVERSITY of Queensland researchers have discovered a way of predicting cancer-free survival in breast cancer patients and identified a new treatment target.

The researchers, led by Professor George Muscat from UQ's Institute for Molecular Bioscience (IMB), has found that breast cancer patients with a particular genetic 'signature' are more likely to survive without their cancer spreading.

Professor Muscat and his team also identified a protein that could be targeted by cancer drugs.

"We examined tissue samples from over 100 breast cancer patients and discovered that those with low levels of the enzyme PRMT2 had a better chance of surviving without their cancer metastasising," Professor Muscat said.

"This enzyme has the ability to affect hundreds of genes so we also examined these genes and the proteins they produce.

"We identified one of these proteins, RORγ, as a druggable protein, meaning it appears to be a good target for treatment."

Professor Muscat said this discovery suggests in future doctors will be able to more confidently predict outcomes in some breast cancer patients, and subsequently improve treatment regimes.

"It also opens the way to develop a new and novel drug for the treatment of breast cancer."

Professor Muscat and his team are now beginning to examine experimental drugs that target RORγ   to evaluate if any are suitable to decrease the growth of tumours and control metastasis.

Cancer Council Queensland spokesperson Katie Clift said the organisation was proud to fund Professor Muscat's research with a grant of $100,000 for 2014.

"Professor Muscat's research is very promising and we look forward to his findings assisting future treatment of breast cancer, improving survival rates in Queensland.

"Around 2900 Queenslanders are diagnosed with breast cancer every year, and about 500 people die from the disease.

"Funding local studies is imperative, and we are proud to see such world-class research being undertaken at the University of Queensland."

The discovery, published in scientific journal Molecular Endocrinology, was supported by The University of Queensland and Cancer Council Queensland and used samples and data provided by a National Breast Cancer Foundation Collaborative Research Program.

IMB  acknowledges the contributions of co-authors PhD student Tae Gyu Oh, Dr Peter Bailey, Dr Eloise Dray, Dr Aaron Smith and Dr Dennis Dowhan, and members of the NBCF Collaborative Research Program.

The Institute for Molecular Bioscience, a research institute of The University of Queensland, aims to improve quality of life by advancing medical genomics, drug discovery and biotechnology.

More information about Cancer Council Queensland is available at www.cancerqld.org.au or 13 11 20.
 

Topics:  breast cancer, cancer council



Nine males, one female; divers watch turtles get frisky

Mating season ends this month.

One female, nine males, this is all part of nature for turtles

Unlike: the Facebook scam targeting Bundy businesses

ALARM BELLS: Cool Bananas co-owner Sharlene Gemming managed to avoid the phishing trap. Photo: Eliza Goetze / NewsMail

Scammers are targetting local cafes on Facebook

Local Partners

Bonus point gets Dan and Carleen over the line on The Block

Dan and Carleen in their winning living and dining rooms in a scene from The Block.

BABY boomers win living and dining week as show hits halfway mark.

Olivia Wilde having a girl

Olivia Wilde revealed she is expecting a baby girl.

Michael Palin: Terry Jones dementia is 'painful' to see

Michael Palin has found Terry Jones' decline "painful to watch"

Daniel Radcliffe hoped for haircut anonymity

Radcliffe thought shaving his head would make him more anonymous

Jim Carrey slams 'shameful greed' of lawsuit

Jim Carrey has slammed the "shameful greed" of White's ex-husband.

'Highly unlikely' Brad Pitt will face prosecution

It is highly unlikely that Brad Pitt will be prosecuted

Developers boost confidence in Bundaberg property market

Slow and steady growth has always been Bundaberg’s way

Property 200m from ocean selling for just over $100K

BEACHCOMBER PARK: Work has started on a new $19.2 million development at Toogoom.

The estate's developer is offering huge discounts for early buyers.

UPDATE: Former rodeo champ's sale rained out, now back on

Larkhill local Ken Consiglio is having an auction of most of the things on his property.

'People kept showing up and we had to turn them away'

First stages of $25 million housing development underway

New development on Madsen Rd - The Springs.

The blocks of land are much bigger than usual

Couple build their own 'tiny house' for $45k

Holly Bowen and Oli Bucher built their "tiny house" themselves, only hiring a plumber and an electrician. Photo/supplied

The house, which is built on a trailer and can be towed.

Rocky proves prime real estate in latest REIQ report

Kas Woch sold this Wood St home in Depot Hill for $107,000 in August.

A new investor's market as Rocky house prices hit lowest in state