Lifestyle

New breakthrough in breast cancer research

UNIVERSITY of Queensland researchers have discovered a way of predicting cancer-free survival in breast cancer patients and identified a new treatment target.

The researchers, led by Professor George Muscat from UQ's Institute for Molecular Bioscience (IMB), has found that breast cancer patients with a particular genetic 'signature' are more likely to survive without their cancer spreading.

Professor Muscat and his team also identified a protein that could be targeted by cancer drugs.

"We examined tissue samples from over 100 breast cancer patients and discovered that those with low levels of the enzyme PRMT2 had a better chance of surviving without their cancer metastasising," Professor Muscat said.

"This enzyme has the ability to affect hundreds of genes so we also examined these genes and the proteins they produce.

"We identified one of these proteins, RORγ, as a druggable protein, meaning it appears to be a good target for treatment."

Professor Muscat said this discovery suggests in future doctors will be able to more confidently predict outcomes in some breast cancer patients, and subsequently improve treatment regimes.

"It also opens the way to develop a new and novel drug for the treatment of breast cancer."

Professor Muscat and his team are now beginning to examine experimental drugs that target RORγ   to evaluate if any are suitable to decrease the growth of tumours and control metastasis.

Cancer Council Queensland spokesperson Katie Clift said the organisation was proud to fund Professor Muscat's research with a grant of $100,000 for 2014.

"Professor Muscat's research is very promising and we look forward to his findings assisting future treatment of breast cancer, improving survival rates in Queensland.

"Around 2900 Queenslanders are diagnosed with breast cancer every year, and about 500 people die from the disease.

"Funding local studies is imperative, and we are proud to see such world-class research being undertaken at the University of Queensland."

The discovery, published in scientific journal Molecular Endocrinology, was supported by The University of Queensland and Cancer Council Queensland and used samples and data provided by a National Breast Cancer Foundation Collaborative Research Program.

IMB  acknowledges the contributions of co-authors PhD student Tae Gyu Oh, Dr Peter Bailey, Dr Eloise Dray, Dr Aaron Smith and Dr Dennis Dowhan, and members of the NBCF Collaborative Research Program.

The Institute for Molecular Bioscience, a research institute of The University of Queensland, aims to improve quality of life by advancing medical genomics, drug discovery and biotechnology.

More information about Cancer Council Queensland is available at www.cancerqld.org.au or 13 11 20.
 

Topics:  breast cancer, cancer council




Alcohol hampers investigation into hotel assault

ASSAULT: A man was taken to hospital after an incident outside the Central Hotel on Friday night.

Victim unable to tell police what happened

QRL responds to Bundaberg's junior rugby league brawl

Bundaberg police on the scene at Salter Oval after a up to 100 people where invovled in a brawl at a junior game.

The Queensland Rugby League talk about the junior brawl

Latest deals and offers

The Big Music Quiz gives The Block a run for its money

Darren McMullen hosts the TV series The Big Music Quiz.

NEW challenger in TV ratings race shakes up Sunday night.

Britney Spears calls Carpool Karaoke appearance "awkward"

Britney Spears admits her Carpool Karaoke segment was "awkward"

Mariah Carey's sister Alison arrested for prostitution

Mariah Carey's sister has been arrested on charges of prostitution.

VIDEO: What did Thor do during Captain America: Civil War?

Short explains why Thor wasn't in Civil War film.

Hilarious mockumentary features star of the film Chris Hemsworth

Meet Toowoomba's top exotic dancer

WINNERS ARE GRINNERS: Exotic dancers (from left) Alice Morgan, Celeste and Frenchie are heading to the United States after competing in Miss Vault 2017.

Dancers vie for top spot at Toowoomba's only strip club

That's a wrap: Gympie Muster celebrates 35 years in style

Caitlyn Shadbolt performs at the Muster Club on Sunday August 28 at the Gympie Muster.

Country music festival blessed with great weather and bumper crowds

REVEALED: Pat Rafter's $18m Coast house on the market

Check out the photos of the Coast's most expensive property for sale

The "correction we had to have" in Gladstone's rentals

UPWARD MARCH: The rental vacancy rate in Gladstone has improved for the first time in more than a year, providing a confidence boost in the market.

Vacancy rates improve with signs that things are getting betterF

ISLAND FOR SALE: Cheap Fraser Coast island drops price again

Suna Island in the Great Sandy Strait will be auctioned by Ray White Hervey Bay on Saturday morning.

This is the cheapest island you will find for sale in Australia

How a family home can fit on a 250sq m block

This is what you can build on 250m2.

Here's the floor plan of a home built on 250sq m

$100m plan for Curtis Island 'world class' luxury resort

$100 million resort: Top views at Turtle Street at Curtis Island.

"At the moment we think it meets all the town planning approvals.”

Noosa mayor on "red alert" over planning court decision

Mayor Tony Wellington hands down his first budget.

Mayor upset at lack of say about look and feel of Noosa